The Ante Room to the Great Room contains many of the paintings from Spencer House. Once a bedroom, it is now used as an occasional dining room for informal occasions.
Lord Charles Bruce died there in 1897 from smallpox. He was the brother-in-law of Charlotte, Countess Spencer. All materials in the room were burnt, and Charlotte and her sisters made the patchwork to replace the destroyed fabrics. It was known as the Patchwork Bedroom until the mid-1980s.